Best Practices for Indirect Spend Open Purchase Order Reporting

We are a software company. I run the day to day operations for our indirect spend. We use MS AX 2012 (no PR's are still going through email as we are figuring out the best method to implement) We have many challenges that I can discuss. I am interested in learning about how other companies (similar in structure e.g. software company) automate this process as it is killing our productivity at the end of each month. I have about 40 stakeholders and about 250 Open Purchase Orders that require a response from our stakeholders all within a 48 hours time frame. I'm curious if anyone has solved a similar problem? Thanks!